Leukocyte adhesion: Two selectins converge on sulphate

Leukocyte adhesion: Two selectins converge on sulphate

The selectins are a family of cell–cell adhesion proteins that participate in leukocyte–endothelial and leukocyte– platelet interactions [1–4]. The family consists of three members: P-selectin, expressed on activated endothelium and platelets; E-selectin, expressed on activated endothelium; and L-selectin, expressed on circulating leukocytes (Fig. 1). During the process of leukocyte emigration ...

Selectins: critical mediators of leukocyte recruitment.

Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will e...

Endothelial-Leukocyte Adhesion Binds to Selectins and Interferes with Complement Regulatory Protein C1 Inhibitor

Threshold Levels of Fluid Shear Promote Leukocyte Adhesion through Selectins (CD62L,P,E)

Leukocyte adhesion through L-selectin to peripheral node addressin (PNAd, also known as MECA-79 antigen), an L-selectin ligand expressed on high endothelial venules, has been shown to require a minimum level of fluid shear stress to sustain rolling interactions (Finger, E.B., K.D. Puri, R. Alon, M.B. Lawrence, V.H. von Andrian, and T.A. Springer. 1996. Nature (Lond.). 379:266-269). Here, we sho...

leukocyte adhesion deficiency: report of two family related newborn infants

leukocyte adhesion deficiency type 1 (lad 1) is an autosomal recessive hereditary disorder resulting from deficiency of cd18, characterized by recurrent bacterial infections. we report two consanguineous patients with leukocyte adhesion deficiency type 1( lad1). these two infant boy patients were referred to us, within a short period of time, with the complaints of recurrent infections at the a...